Anti-virus software is, as of now, completely unnecessary. Will it be in the future? Maybe, as the Mac's market share increases. but right now, there are zero viruses for the Mac.
If you feel the need to defragment, use
iDefrag. There's an argument over whether or not users need to defrag OS X; one side says the OS automatically defrags files under 20 MB, and because 99% of the files on your system are under this size, it's pointless. The other side says apps like iDefrag not only defrag but also optimize the layout of files on the drive. It has been discovered that while using defragmenting programs on your Mac may make apps open faster, your boot time may be greatly increased.